Therapy Detail

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Therapy Name AG1295
Synonyms
Therapy Description

AG1295 inhibits the tyrosine kinase activity of PDGFRA, PDGFRB, KIT, and FLT3, which may inhibit growth and promote apoptosis in cancer cells (PMID: 11468194, PMID: 7954456, PMID: 29143227).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AG1295 AG-1295|AG 1295 FLT3 Inhibitor 66 KIT Inhibitor 57 PDGFR Inhibitor (Pan) 30 AG1295 inhibits the tyrosine kinase activity of PDGFRA, PDGFRB, KIT, and FLT3, which may inhibit growth and promote apoptosis in cancer cells (PMID: 11468194, PMID: 7954456, PMID: 29143227).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 I836S hematologic cancer no benefit AG1295 Preclinical - Cell culture Actionable In a preclinical study, AG1295 did not inhibit viability of transformed cells expressing FLT3 I836S in culture (PMID: 28077790). 28077790
FLT3 I836T hematologic cancer no benefit AG1295 Preclinical - Cell culture Actionable In a preclinical study, AG1295 did not inhibit viability of transformed cells expressing FLT3 I836T in culture (PMID: 28077790). 28077790
FLT3 Q575del hematologic cancer sensitive AG1295 Preclinical - Cell culture Actionable In a preclinical study, AG1295 decreased downstream signaling and proliferation in transformed cells expressing FLT3 Q575del in culture (PMID: 33914060). 33914060
FLT3 D835K FLT3 D835L hematologic cancer no benefit AG1295 Preclinical - Cell culture Actionable In a preclinical study, AG1295 did not inhibit viability of transformed cells expressing FLT3 D835L and D835K in culture (PMID: 28077790). 28077790
FLT3 I836D FLT3 I836L hematologic cancer no benefit AG1295 Preclinical - Cell culture Actionable In a preclinical study, AG1295 did not inhibit viability of transformed cells expressing FLT3 I836D and I836L in culture (PMID: 28077790). 28077790
FLT3 D835A hematologic cancer no benefit AG1295 Preclinical - Cell culture Actionable In a preclinical study, AG1295 did not inhibit viability of transformed cells expressing FLT3 D835A in culture (PMID: 28077790). 28077790

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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