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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Ki23819||FLT3 Inhibitor 54||Ki23819 inhibits both wild-type FLT3 and FLT3 containing activating internal tandem duplications, which may block downstream signaling and induce apoptosis in cancer cells (PMID: 15815726).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FLT3 exon 14 ins||acute myeloid leukemia||sensitive||Ki23819||Preclinical - Cell culture||Actionable||In a preclinical study, acute myeloid leukemia cells harboring a FLT3 internal tandem duplication were sensitive to Ki23819 in culture, demonstrating inhibition of autophosphorylation and downstream signaling, and reduced cell proliferation (PMID: 15815726).||15815726|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|