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Therapy Name Bazlitoran
Synonyms
Therapy Description

Bazlitoran (IMO-8400) is a TLR 7, 8 and 9 antagonist, which leads to decreased growth of tumors with activated TLR signaling (Cancer Res October 1, 2014 74:2570, PMID: 27876460).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Bazlitoran IMO-8400 Bazlitoran (IMO-8400) is a TLR 7, 8 and 9 antagonist, which leads to decreased growth of tumors with activated TLR signaling (Cancer Res October 1, 2014 74:2570, PMID: 27876460).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02252146 Phase Ib/II Bazlitoran Dose Escalation Study in Patients With Relapsed or Refractory DLBCL and MyD88L265P Mutation Completed USA 0
NCT02092909 Phase Ib/II Bazlitoran Phase 1/2 Dose Escalation Study in Patients With Relapsed or Refractory Waldenstrom's Macroglobulinemia (8400-401) Terminated USA 0


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