Therapy Detail

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Therapy Name TH-4000
Synonyms
Therapy Description

TH-4000 is a pan-HER inhibitor prodrug, which is activated within hypoxic tumor conditions, potentially resulting in decreased proliferation of HER-expressing tumor cells (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
TH-4000 PR610|Hypoxin|TRLX|Tarloxotinib bromide|Tarloxotinib EGFR Inhibitor (Pan) 55 HER2 Inhibitor 38 TH-4000 (tarloxotinib) is a prodrug that is converted to an irreversible Egfr/Erbb2 (Her2)/Erbb4 inhibitor under hypoxia, potentially resulting in inhibition of tumor cell growth (PMID: 33355298).

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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01631279 Phase Ib/II TH-4000 A Dose Escalation Trial of PR610 Treating Patients With Solid Tumors Terminated USA 1
NCT02454842 Phase II TH-4000 Study for Treatment of Patients With EGFR Mutant, T790M-negative NSCLC Terminated USA 1
NCT02449681 Phase II TH-4000 Study for Treatment of Patients With Recurrent or Metastatic SCCHN or SCCS Terminated USA 1
NCT03805841 Phase II TH-4000 Study of Tarloxotinib in Pts With NSCLC (EGFR Exon 20 Insertion, HER2-activating Mutations) & Other Solid Tumors With NRG1/ERBB Gene Fusions (RAIN) Terminated USA | CAN 1


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