Therapy Detail

Therapy Name EKI-285
Synonyms
Therapy Description

EKI-285 is a small molecule inhibitor of EGFR, leading to decreased growth of EGFR-expressing tumors (PMID: 10086326, PMID: 11818567).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
EKI-285 CL-387,785|CL-387785 EGFR Inhibitor (Pan) 43 EKI-285 is a small molecule inhibitor of EGFR, leading to decreased growth of EGFR-expressing tumors (PMID: 10086326, PMID: 11818567).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 L755P Advanced Solid Tumor sensitive EKI-285 Preclinical Actionable In a preclinical study, EKI-285 (CL-387785) inhibited proliferation of transformed cell lines expressing ERBB2 (HER2) L755P in culture (PMID: 22046346). 22046346
EGFR L858R EGFR E884K Advanced Solid Tumor sensitive EKI-285 Preclinical Actionable In a preclinical study, cells expressing the double EGFR L858R/E884K mutation demonstrated increased sensitivity to inhibition of Egfr phosphorylation by EKI-285 compared to cells expressing EGFR L858R alone (PMID: 20942962). 20942962
EGFR L858R Advanced Solid Tumor sensitive EKI-285 Preclinical Actionable In a preclinical study, EKI-285 (CL-387,785) inhibited growth of transformed cells expressing EGFR L858R in culture (PMID: 17085664). 17085664
EGFR L718Q Advanced Solid Tumor sensitive EKI-285 Preclinical Actionable In a preclinical study, EKI-285 inhibited EGFR phosphorylation and growth of cells expressing EGFR L718Q in culture (PMID: 25948633). 25948633
ERBB2 T798M Advanced Solid Tumor sensitive EKI-285 Preclinical Actionable In a preclinical study, EKI-285 (CL-387785) inhibited proliferation of transformed cell lines expressing ERBB2 (HER2) T798M in culture (PMID: 22046346). 22046346
EGFR H773L lung non-small cell carcinoma resistant EKI-285 Preclinical - Cell culture Actionable In a preclinical study, non-small cell lung cancer cells expressing EGFR H773L were resistant to EKI-285 (CL-387,785) induced Egfr signaling inhibition and apoptosis in culture (PMID: 17974985). 17974985
EGFR L858R EGFR T790M Advanced Solid Tumor decreased response EKI-285 Preclinical Actionable In a preclinical study, transformed cells expressing EGFR L858R and T790M demonstrated decreased sensitivity to EKI-285 (CL-387,785) in culture (PMID: 17085664). 17085664
EGFR L844V Advanced Solid Tumor sensitive EKI-285 Preclinical Actionable In a preclinical study, EKI-285 inhibited EGFR phosphorylation and growth of cells expressing EGFR L844V in culture (PMID: 25948633). 25948633
EGFR D761Y EGFR L858R Advanced Solid Tumor sensitive EKI-285 Preclinical Actionable In a preclinical study, EKI-285 (CL-387,785) inhibited growth of transformed cells expressing EGFR L858R and EGFR D716Y in culture (PMID: 17085664). 17085664
ERBB2 L755S Advanced Solid Tumor sensitive EKI-285 Preclinical Actionable In a preclinical study, EKI-285 (CL-387785) inhibited proliferation of transformed cell lines expressing ERBB2 (HER2) L755S in culture (PMID: 22046346). 22046346

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Clinical Trial Phase Therapies Title Recruitment Status


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