Therapy Detail

Therapy Name EKI-285
Synonym
Therapy Description

EKI-285 is a small molecule inhibitor of EGFR, leading to decreased growth of EGFR-expressing tumors (PMID: 10086326, PMID: 11818567).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
EKI-285 CL-387,785|CL-387785 EGFR Inhibitor (Pan) 38 EKI-285 is a small molecule inhibitor of EGFR, leading to decreased growth of EGFR-expressing tumors (PMID: 10086326, PMID: 11818567).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 L755P Advanced Solid Tumor sensitive EKI-285 Preclinical Actionable In a preclinical study, EKI-285 (CL-387785) inhibited proliferation of transformed cell lines expressing ERBB2 (HER2) L755P in culture (PMID: 22046346). 22046346
ERBB2 T798M Advanced Solid Tumor sensitive EKI-285 Preclinical Actionable In a preclinical study, EKI-285 (CL-387785) inhibited proliferation of transformed cell lines expressing ERBB2 (HER2) T798M in culture (PMID: 22046346). 22046346
ERBB2 L755S Advanced Solid Tumor sensitive EKI-285 Preclinical Actionable In a preclinical study, EKI-285 (CL-387785) inhibited proliferation of transformed cell lines expressing ERBB2 (HER2) L755S in culture (PMID: 22046346). 22046346
Clinical Trial Phase Therapies Title Recruitment Status