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Therapy Name Omaveloxolone
Synonyms
Therapy Description

Omaveloxolone (RTA 408) is an activator of Nrf2 and inhibitor of NF-kappa B, which inhibits tumor growth through regulation of antioxidant and pro-inflammatory gene expression (PMID: 25897966).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Omaveloxolone RTA 408|RTA-408 Omaveloxolone (RTA 408) is an activator of Nrf2 (NFE2L2) and inhibitor of NF-kappa B, which inhibits tumor growth through regulation of antioxidant and pro-inflammatory gene expression (PMID: 25897966, PMID: 31487581).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable Omaveloxolone Preclinical - Cell culture Actionable In a preclinical study, Omaveloxolone (RTA 408) induced apoptosis and inhibited growth of several human tumor cell lines in culture (PMID: 25897966). 25897966
Unknown unknown Advanced Solid Tumor not applicable Omaveloxolone Phase I Actionable In a Phase I trial, treatment with Omaveloxolone (RTA 408) in patients with an advanced solid tumor led to a median progression-free survival of 1.5 months, an overall survival of 5.8 months, and one patient with lung cancer experienced stable disease for greater than 12 months (PMID: 28919776). 28919776

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status
NCT02259231 Phase Ib/II Ipilimumab Nivolumab Omaveloxolone RTA 408 Capsules in Patients With Melanoma - REVEAL Completed


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