Therapy Detail

Therapy Name WZ4002
Synonyms
Therapy Description

WZ4002 is a mutant-selective irreversible EGFR inhibitor that inhibits proliferation of tumor cells, including those harboring EGFR T790M (PMID: 20033049).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
WZ4002 EGFR Inhibitor 3rd gen 17 WZ4002 is a mutant-selective irreversible EGFR inhibitor that inhibits proliferation of tumor cells, including those harboring EGFR T790M (PMID: 20033049).

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  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
EGFR C797S EGFR exon 19 del Advanced Solid Tumor resistant WZ4002 Preclinical Actionable In a preclinical study, transformed human cells harboring EGFR exon 19 deletion and EGFR C797S were resistant to WZ4002 induced suppression of EGFR signaling in culture (PMID: 25964297). 25964297
ERBB2 T798M Advanced Solid Tumor sensitive WZ4002 Preclinical Actionable In a preclinical study, WZ4002 inhibited proliferation of transformed cell lines expressing ERBB2 (HER2) T798M in culture (PMID: 22046346). 22046346
EGFR C797S EGFR exon 19 del EGFR T790M Advanced Solid Tumor conflicting WZ4002 Preclinical Actionable In a preclinical study, WZ4002 treatment resulted in partial inhibition of EGFR signaling in transformed human cells over expressing EGFR exon 19 deletion, EGFR T790M and EGFR C797S when T790M and C797S were expressed in trans, but no EGFR inhibition when T790M and C797S were expressed in cis (PMID: 25964297). 25964297
EGFR exon 19 del EGFR T790M lung non-small cell carcinoma sensitive WZ4002 Preclinical - Cell culture Actionable In a preclinical study, WZ4002 inhibited EGFR signaling and cell growth in 1st generation TKI-resistant non-small cell lung cancer cells harboring EGFR exon 19 deletion and EGFR T790M in culture (PMID: 25964297). 25964297
EGFR exon 19 del EGFR T790M Advanced Solid Tumor sensitive WZ4002 Preclinical - Cell culture Actionable In a preclinical study, WZ4002 inhibited EGFR signaling in transformed human cells over expressing EGFR exon 19 deletion and EGFR T790M in culture (PMID: 25964297). 25964297
EGFR exon 19 del NRAS Q61K lung non-small cell carcinoma resistant WZ4002 Preclinical Actionable In a preclinical study, non-small cell lung cancer cells harboring EGFR exon 19 deletion became resistant to WZ4002 after the emergence of NRAS Q61K in culture (PMID: 25870145). 25870145
EGFR C797S EGFR exon 19 del EGFR T790M lung adenocarcinoma resistant WZ4002 Preclinical Actionable In a preclinical study, lung adenocarcinoma cells over expressing EGFR exon 19 deletion, EGFR T790M and EGFR C797S in cis were resistant to WZ4002 induced suppression of EGFR signaling and growth inhibition in culture (PMID: 25964297). 25964297
ERBB2 L755S Advanced Solid Tumor sensitive WZ4002 Preclinical Actionable In a preclinical study, WZ4002 inhibited proliferation of transformed cell lines expressing ERBB2 (HER2) L755S in culture (PMID: 22046346). 22046346
EGFR E746_A750del EGFR C797S lung non-small cell carcinoma resistant WZ4002 Preclinical - Cell culture Actionable In a preclinical study, a non-small cell lung cancer cell line harboring EGFR E746_A750del and expressing EGFR E746_A750del/C797S demonstrated resistance to growth inhibition by WZ4002 in culture (PMID: 25948633). 25948633
EGFR C797S EGFR exon 19 del lung adenocarcinoma resistant WZ4002 Preclinical Actionable In a preclinical study, lung adenocarcinoma cells over expressing EGFR exon 19 deletion and EGFR C797S were resistant to WZ4002 induced suppression of EGFR signaling and growth inhibition in culture (PMID: 25964297). 25964297
ERBB2 L755P Advanced Solid Tumor sensitive WZ4002 Preclinical Actionable In a preclinical study, WZ4002 inhibited proliferation of transformed cell lines expressing ERBB2 (HER2) L755P in culture (PMID: 22046346). 22046346
EGFR C797S EGFR exon 19 del EGFR T790M lung non-small cell carcinoma resistant WZ4002 Preclinical Actionable In a preclinical study, non-small cell lung carcinoma cells harboring EGFR exon 19 deletion, EGFR T790M and EGFR C797S were resistant to WZ4002 induced suppression of EGFR signaling and growth inhibition in culture, regardless of the allelic context of EGFR T790M and EGFR C797S (PMID: 25964297). 25964297

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  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status


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