Therapy Detail

Therapy Name WZ4002
Therapy Description

WZ4002 is a mutant-selective irreversible EGFR inhibitor that inhibits proliferation of tumor cells, including those harboring EGFR T790M (PMID: 20033049).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
WZ4002 EGFR Inhibitor 3rd gen 16 WZ4002 is a mutant-selective irreversible EGFR inhibitor that inhibits proliferation of tumor cells, including those harboring EGFR T790M (PMID: 20033049).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 T798M Advanced Solid Tumor sensitive WZ4002 Preclinical Actionable In a preclinical study, WZ4002 inhibited proliferation of transformed cell lines expressing ERBB2 (HER2) T798M in culture (PMID: 22046346). 22046346
ERBB2 L755P Advanced Solid Tumor sensitive WZ4002 Preclinical Actionable In a preclinical study, WZ4002 inhibited proliferation of transformed cell lines expressing ERBB2 (HER2) L755P in culture (PMID: 22046346). 22046346
ERBB2 L755S Advanced Solid Tumor sensitive WZ4002 Preclinical Actionable In a preclinical study, WZ4002 inhibited proliferation of transformed cell lines expressing ERBB2 (HER2) L755S in culture (PMID: 22046346). 22046346
Clinical Trial Phase Therapies Title Recruitment Status