Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|UMI-77||UMI77|UMI 77||MCL1 Inhibitor 18||UMI-77 is a small molecule drug that selectively inhibits MCL1, which leads to increased tumor cell apoptosis and decreased tumor cell growth (PMID: 24019208, PMID: 30796196).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PTEN loss||glioblastoma||sensitive||UMI-77||Preclinical - Cell culture||Actionable||In a preclinical study, UMI-77 treatment led to enhanced apoptosis, reduced Akt phosphorylation, and inhibited proliferation, colony formation, spheroid formation, and neurosphere formation in PTEN-deficient glioblastoma cell lines in culture (PMID: 32737157).||32737157|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|