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Therapy Name Verteporfin
Synonyms
Therapy Description

Visudyne (verteporfin) is a small molecule that binds to YAP and inhibits the interaction between YAP and TEAD, potentially resulting in decreased growth of YAP-driven tumor cells (PMID: 22677547). Verteporfin is FDA-approved for treatment of age-related macular degeneration (FDA.gov).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Verteporfin Visudyne YAP Inhibitor 2 Visudyne (verteporfin) is a small molecule that binds to YAP1 and inhibits the interaction between YAP1 and TEAD, potentially resulting in decreased growth of YAP-driven tumor cells (PMID: 22677547, PMID: 28576749). Verteporfin is FDA-approved for treatment of age-related macular degeneration (FDA.gov).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown neuroblastoma not applicable Verteporfin Preclinical - Cell line xenograft Actionable In a preclinical study, verteporfin inhibited growth and metastasis of neuroblastoma cell lines in culture, and pretreatment of a metastatic subpopulation of a neuroblastoma cell line with verteporfin decreased metastasis in xenograft models (PMID: 27899382). 27899382

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02939274 Phase II Verteporfin An Open Label, Phase II Trial of Continuous Low-Irradiance Photodynamic Therapy (CLIPT) Using Verteporfin (Visudyne) for the Treatment of Cutaneous Metastases of Breast Cancer Unknown status USA 0
NCT03033225 Phase II Verteporfin EUS-guided PDT in Pancreatic Tumors Recruiting USA 0
NCT04590664 Phase Ib/II Verteporfin Verteporfin for the Treatment of Recurrent High Grade EGFR-Mutated Glioblastoma Recruiting USA 0
NCT02464761 Phase I Verteporfin Photodynamic Therapy for the Treatment of Vertebral Metastases Completed CAN 0
NCT03067051 Phase I Verteporfin Clinical Study to Assess the Safety and Adequacy of Effectiveness of the SpectraCure P18 System Recruiting USA | CAN 1


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