Therapy Detail

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Therapy Name Verteporfin
Synonyms
Therapy Description

Visudyne (verteporfin) is a small molecule that binds to YAP and inhibits the interaction between YAP and TEAD, potentially resulting in decreased growth of YAP-driven tumor cells (PMID: 22677547). Verteporfin is FDA-approved for treatment of age-related macular degeneration (FDA.gov).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Verteporfin Visudyne YAP Inhibitor 2 Visudyne (verteporfin) is a small molecule that binds to YAP1 and inhibits the interaction between YAP1 and TEAD, potentially resulting in decreased growth of YAP-driven tumor cells (PMID: 22677547, PMID: 28576749). Verteporfin is FDA-approved for treatment of age-related macular degeneration (FDA.gov).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown neuroblastoma not applicable Verteporfin Preclinical - Cell line xenograft Actionable In a preclinical study, verteporfin inhibited growth and metastasis of neuroblastoma cell lines in culture, and pretreatment of a metastatic subpopulation of a neuroblastoma cell line with verteporfin decreased metastasis in xenograft models (PMID: 27899382). 27899382
GNAQ Q209L uveal melanoma sensitive Verteporfin Preclinical - Cell line xenograft Actionable In a preclinical study, Visudyne (verteporfin) inhibited tumor formation in a uveal melanoma cell line xenograft model harboring GNAQ Q209L (PMID: 27308390). 27308390

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
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Clinical Trial Phase Therapies Title Recruitment Status
NCT02464761 Phase I Verteporfin Photodynamic Therapy for the Treatment of Vertebral Metastases Completed
NCT03033225 Phase II Verteporfin EUS-guided PDT in Pancreatic Tumors Recruiting
NCT03067051 Phase I Verteporfin Clinical Study to Assess the Safety and Adequacy of Effectiveness of the SpectraCure P18 System Recruiting
NCT02939274 Phase II Verteporfin An Open Label, Phase II Trial of Continuous Low-Irradiance Photodynamic Therapy (CLIPT) Using Verteporfin (Visudyne) for the Treatment of Cutaneous Metastases of Breast Cancer Unknown status


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