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SEL24-B489 is an inhibitor of PIM kinases 1, 2, 3, and FLT3, which may suppress cell growth and induce apoptosis (Blood 126 (23):706.December 2015).
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|SEL24-B489||SEL24|SEL 24|MEN1703|MEN-1703||FLT3 Inhibitor 55 PIM Inhibitor (Pan) 9||SEL24-B489 (MEN1703) is an inhibitor of PIM kinases 1, 2, 3, and FLT3, which may suppress cell growth and induce apoptosis (Blood 126 (23):706.December 2015, PMID: 29682194).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||diffuse large B-cell lymphoma||not applicable||SEL24-B489||Preclinical - Cell line xenograft||Actionable||In a preclinical study, SEL24-B489 treatment induced apoptosis in diffuse large B-cell lymphoma cells in both culture and xenograft models (Blood 126 (23):706.December 2015).||detail...|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT03008187||Phase Ib/II||SEL24-B489||SEL24 in Patients With AML||Recruiting||USA||3|