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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|NSC156529||Akt1 Inhibitor 6||NSC156529 is a small molecule that blocks the interaction between Pdpk1 and Akt1 resulting in inhibition of Akt1 signaling, which may result in decreased tumor growth (PMID: 26294745).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||prostate cancer||not applicable||NSC156529||Preclinical - Cell line xenograft||Actionable||In a preclinical study, NSC156529 inhibited growth of human prostate cancer cell lines in culture, induced expression of differentiation markers and inhibited tumor growth in cell line xenograft models (PMID: 26294745).||26294745|
|Unknown unknown||Advanced Solid Tumor||not applicable||NSC156529||Preclinical||Actionable||In a preclinical study, NSC156529 inhibited growth of transformed human cell lines in culture (PMID: 26294745).||26294745|
|Unknown unknown||hepatocellular carcinoma||not applicable||NSC156529||Preclinical||Actionable||In a preclinical study, NSC156529 inhibited growth of human hepatocellular carcinoma cell lines in culture (PMID: 26294745).||26294745|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|