Therapy Detail

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Therapy Name AGS16F
Synonyms
Therapy Description

AGS16F is a monoclonal antibody against ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3) linked to the cytotoxic drug monomethyl auristatin F (MMAF), which may result in apoptosis of ENPP3-expressing tumor cells and decreased tumor growth (PMID: 26589436).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AGS16F AGS16C3F|AGS16M8F|AGS-16C3F|AGS-16M8F AGS16F is a monoclonal antibody against ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3) linked to the cytotoxic drug monomethyl auristatin F (MMAF), which may result in apoptosis of ENPP3-expressing tumor cells and decreased tumor growth (PMID: 26589436).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown renal cell carcinoma not applicable AGS16F Phase I Actionable In a Phase I trial, treatment with AGS16F (AGS-16CSF) at the recommended phase 2 dose demonstrated safety and resulted in a partial response in 23% (3/13) of patients with metastatic renal cell carcinoma including 2 patients with clear cell and 1 patient with papillary histology, and a disease control rate of 92% (12/13) (PMID: 29848572). 29848572

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status
NCT02639182 Phase II AGS16F Axitinib A Study of AGS-16C3F vs. Axitinib in Metastatic Renal Cell Carcinoma Active, not recruiting


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