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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|IMR-1||NOTCH Inhibitor (Pan) 5||IMR-1 (inhibitor of mastermind recruitment-1) is a small molecule inhibitor of the Notch transcriptional activation complex, resulting in repression of Notch target gene expression and possibly leading to inhibition of tumor growth (PMID: 27197169).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||esophagus adenocarcinoma||not applicable||IMR-1||Preclinical - Cell line xenograft||Actionable||In a preclinical study, IMR-1 treatment of esophageal adenocarcinoma cells resulted in decreased colony formation in culture and inhibition of tumor growth in xenograft models (PMID: 27197169).||27197169|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|