Therapy Detail

Therapy Name Trifluridine
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Trifluridine F3DThd FTD|trifluorothymidine
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 wild-type colon cancer sensitive Trifluridine Preclinical - Cell culture Actionable In a preclinical study, treatment with Trifluridine (FTD) resulted in Tp53-dependent cell-cycle arrest and decreased expression of CyclinB1 and Cdk1 in a Tp53-proficient colon cancer cancer cell line in culture (PMID: 25700705). 25700705
Clinical Trial Phase Therapies Title Recruitment Status
NCT03223779 Phase Ib/II Trifluridine Study of TAS-102 Plus Radiation Therapy for the Treatment of the Liver in Patients With Hepatic Metastases From Colorectal Cancer Recruiting