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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|KPT-9274||KPT-9274 is a dual inhibitor of PAK4 and NAMPT, which blocks the PAK4 and NAD pathways, possibly resulting in inhibition of tumor growth (PMID: 27390344).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||KPT-9274||Phase I||Actionable||In a Phase I trial, KPT-9274 treatment resulted in stable disease in 29% (4/14) of patients with advanced solid tumors (Ann Oncol 2017, Vol 28, Suppl 5, Abstract # 374PD; NCT02702492).||detail...|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT02702492||Phase I||KPT-9274 KPT-9274 + Niacin||PAK4 and NAMPT in Patients With Solid MAlignancies or NHL (PANAMA) (PANAMA)||Recruiting|