Therapy Detail
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| Therapy Name | Enobosarm |
| Synonyms | |
| Therapy Description |
Ostarine (enobosarm) is a nonsteroidal selective androgen receptor modulator that mimics testosterone function, which is currently used to treat cachexia in cancer patients (PMID: 24490605). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Enobosarm | GTx-024|MK-2866|Ostarine | Ostarine (enobosarm) is a nonsteroidal selective androgen receptor modulator that mimics testosterone function, which is currently used to treat cachexia in cancer patients (PMID: 24490605). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02368691 | Phase II | Enobosarm | Efficacy and Safety of GTx-024 in Patients With Androgen Receptor-Positive Triple Negative Breast Cancer (AR+ TNBC) | Terminated | USA | 0 |
| NCT02463032 | Phase II | Enobosarm | Efficacy and Safety of GTx-024 in Patients With ER+/AR+ Breast Cancer | Completed | USA | 0 |
| NCT04869943 | Phase III | Exemestane Enobosarm | Efficacy Evaluation of Enobosarm Monotherapy in Treatment of AR+/ER+/HER2- Metastatic Breast Cancer (ARTEST) | Terminated | USA | ESP | 2 |
| NCT02746328 | Phase II | Enobosarm | Add-on Study for Protocol G200802 (NCT02463032): Effect of GTx-024 on Maximal Neuromuscular Function and Lean Body Mass | Withdrawn | USA | 0 |
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