Therapy Detail

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Therapy Name T-3775440
Synonyms
Therapy Description

T-3775440 is a small molecule inhibitor of KDM1A (LSD1), which may lead to antileukemic activity, including apoptotic activity and inhibition of tumor growth (PMID: 27903753).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
T-3775440 KDM1A Inhibitor 12 T-3775440 is a small molecule inhibitor of KDM1A (LSD1), which may lead to antileukemic activity, including apoptotic activity and inhibition of tumor growth (PMID: 27903753).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown lung small cell carcinoma not applicable T-3775440 Preclinical - Cell line xenograft Actionable In a preclinical study, T-3775440 treatment led to decreased cell proliferation in lung small cell carcinoma cell lines in culture, demonstrating reduced expression of INSM1 or GFI1B, and inhibited tumor growth in lung small cell carcinoma cell line xenograft models (PMID: 28667074). 28667074
Unknown unknown acute lymphoblastic leukemia no benefit T-3775440 Preclinical - Cell culture Actionable In a preclinical study, an acute lymphocytic leukemia cell line did not respond to treatment with T-3775440 in culture, demonstrating minimal to no cell growth inhibition (PMID: 27903753). 27903753
Unknown unknown acute myeloid leukemia not applicable T-3775440 Preclinical - Cell line xenograft Actionable In a preclinical study, T-3775440 resulted in cell cycle arrest and apoptotic activity in cell lines of acute erythroid leukemia and acute megakaryoblastic leukemia, and resulted in suppression of tumor growth in xenograft models of both types of cell lines (PMID: 27903753). 27903753

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status


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