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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|T-3775440||KDM1A Inhibitor 12||T-3775440 is a small molecule inhibitor of KDM1A (LSD1), which may lead to antileukemic activity, including apoptotic activity and inhibition of tumor growth (PMID: 27903753).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||lung small cell carcinoma||not applicable||T-3775440||Preclinical - Cell line xenograft||Actionable||In a preclinical study, T-3775440 treatment led to decreased cell proliferation in lung small cell carcinoma cell lines in culture, demonstrating reduced expression of INSM1 or GFI1B, and inhibited tumor growth in lung small cell carcinoma cell line xenograft models (PMID: 28667074).||28667074|
|Unknown unknown||acute lymphoblastic leukemia||no benefit||T-3775440||Preclinical - Cell culture||Actionable||In a preclinical study, an acute lymphocytic leukemia cell line did not respond to treatment with T-3775440 in culture, demonstrating minimal to no cell growth inhibition (PMID: 27903753).||27903753|
|Unknown unknown||acute myeloid leukemia||not applicable||T-3775440||Preclinical - Cell line xenograft||Actionable||In a preclinical study, T-3775440 resulted in cell cycle arrest and apoptotic activity in cell lines of acute erythroid leukemia and acute megakaryoblastic leukemia, and resulted in suppression of tumor growth in xenograft models of both types of cell lines (PMID: 27903753).||27903753|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|