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|Therapy Name||MVAp53 + Pembrolizumab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|MVAp53||p53MVA||p53 Vaccine 5||MVAp53 is a modified vaccinia virus Ankara-based vaccine that may induce a T-cell mediated immune response against p53-expressing tumor cells (PMID: 21843052, PMID: 30094792).|
|Pembrolizumab||Keytruda||MK-3475||Immune Checkpoint Inhibitor 98 PD-L1/PD-1 antibody 67||Keytruda (pembrolizumab) is an antibody against PD-1 that activates T-cell mediated anti-tumor immune response (PMID: 25977344). Keytruda (pembrolizumab) is approved in melanoma, SCLC, HNSCC, classical Hodgkin Lymphoma, primary mediastinal large B-cell lymphoma, urothelial carcinoma, HCC, Merkel cell carcinoma, NMIBC, cutaneous squamous cell carcinoma, MSI-H or dMMR or TMB high advanced solid tumors, PD-L1 expressing NSCLC, gastric and GEJ adenocarcinoma, squamous esophageal carcinoma, cervical cancer, and triple-negative breast cancer, in combination with pemetrexed and platinum in non-squamous NSCLC with no EGFR or ALK mutations, with carboplatin and paclitaxel/nab-paclitaxel in squamous NSCLC, with axitinib in RCC, with Lenvatinib in endometrial carcinoma that is not MSI-H or dMMR, and in combination with platinum and fluoropyrimidine-based chemotherapy for patients with esophageal or gastroesophageal carcinoma (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||MVAp53 + Pembrolizumab||Phase I||Actionable||In a Phase I trial, MVAp53 and Keytruda (pembrolizumab) combination therapy demonstrated safety and preliminary efficacy, resulting in a clinical response in 27.3% (3/11) of patients with advanced solid tumors, who remained with stable disease for up to 49 weeks (PMID: 30094792).||30094792|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT02432963||Phase I||MVAp53 + Pembrolizumab||Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy||Active, not recruiting||USA||0|
|NCT03113487||Phase II||MVAp53 + Pembrolizumab||P53MVA and Pembrolizumab in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer||Recruiting||USA||0|