Therapy Detail

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Therapy Name CX-2009
Synonyms
Therapy Description

CX-2009 is a probody drug conjugate consisting of the cytotoxic agent, maytansinoid DM4, and an antibody to the tumor associate antigen, CD166 (ALCAM), with a masking peptide that is cleaved by proteases specific to tumor cells (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CX-2009 CX2009|CX 2009|Praluzatamab ravtansine CX-2009 (Praluzatamab ravtansine) is a probody drug conjugate consisting of the cytotoxic agent, maytansinoid DM4, and an antibody to the tumor associate antigen, CD166 (ALCAM), with a masking peptide that is cleaved by proteases specific to tumor cells (PMID: 32483421).

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  • Case insensitive filtering will display rows where any text in any cell matches the filter term
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  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03149549 Phase Ib/II CX-2009 PROCLAIM-CX-2009: A Trial to Find Safe and Active Doses of an Investigational Drug CX-2009 for Patients With Selected Solid Tumors Completed USA 3
NCT04596150 Phase II CX-2009 CX-072 + CX-2009 Study to Evaluate the Safety and Antitumor Activity of CX-2009 Monotherapy and in Combination With CX-072 in Advanced Breast Cancer Recruiting USA 0


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