Therapy Detail

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Therapy Name SM88
Synonyms
Therapy Description

SM88 is a 4-component combination consists of tyrosine isomers and 3 low dose repurposed drugs including Cyp3a4 inducer, mTOR inhibitor, and oxidative stress modulator, which may selectively kill tumor cells (J Clin Oncol 35, 2017 (suppl; abstr e14061)).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
SM88 SM-88|Racemetyrosine|Racemetirosine SM88 is a modified tyrosine derivative that may interfere with protein synthesis, leading to oxidative damage and cell death in tumor cells (PMID: 31358523, PMID: 30929156).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown prostate cancer not applicable SM88 Phase II Actionable In a Phase II trial, SM-88 treatment resulted in stable (4/10) or rising (5/10) testosterone levels, and none of the toxicity commonly associated with androgen deprivation therapy in patients with non-metastatic recurrent prostate cancer (J Clin Oncol 36, 2018 (suppl 6S; abstr 175); NCT02796898). detail...

Filtering

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  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
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Clinical Trial Phase Therapies Title Recruitment Status
NCT02796898 Phase Ib/II SM88 Study of the Efficacy, Safety, and Pharmacokinetics of SM88 in Patients With Prostate Cancer Completed


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