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Therapy Name UCART19
Synonyms
Therapy Description

UCART19 are allogeneic T-cells engineered to knockout TCR alpha and CD52, and co-express a chimeric antigen receptor targeting CD19 and Rqr8, that demonstrated anti-tumor activity (J Clin Oncol 33, 2015 (suppl; abstr 3069)).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
UCART19 S68587|ALLO-501|TCR/CD52-deficient RQR8+ CD19-CART UCART19 are allogeneic T-cells engineered to knockout TCR alpha and CD52, and co-express a chimeric antigen receptor targeting CD19 and Rqr8, which demonstrates anti-tumor activity (J Clin Oncol 33, 2015 (suppl; abstr 3069)).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03939026 Phase I UCART19 ALLO-647 + Cyclophosphamide + Fludarabine Safety and Efficacy of ALLO-501 Anti-CD19 Allogeneic CAR T Cells in Adults With Relapsed/Refractory Large B Cell or Follicular Lymphoma (ALPHA) Active, not recruiting USA 0
NCT02808442 Phase I UCART19 Study of UCART19 in Pediatric Patients With Relapsed/Refractory B Acute Lymphoblastic Leukemia (PALL) Completed USA 3
NCT02746952 Phase I UCART19 Dose Escalation Study of UCART19 in Adult Patients With Relapsed / Refractory B-cell Acute Lymphoblastic Leukaemia (CALM) Completed USA 3


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