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Therapy Name | GNE-781 |
Synonyms | |
Therapy Description |
GNE-781 is an inhibitor that targets the bromodomain of CREBBP and EP300, which results in suppression of Myc, and subsequently, may lead to antitumor activity (PMID: 28892380). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
GNE-781 | GNE-781 is an inhibitor that targets the bromodomain of CREBBP and EP300, which results in suppression of Myc, and subsequently, may lead to antitumor activity (PMID: 28892380, PMID: 32371576). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Unknown unknown | acute myeloid leukemia | not applicable | GNE-781 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, GNE-781 treatment resulted in tumor growth inhibition and reduced MYC transcript levels in acute myeloid leukemia cell line xenograft models (PMID: 28892380). | 28892380 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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