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|Therapy Name||Radiotherapy + XL-844|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|XL-844||CHK Inhibitor (Pan) 2||XL-884 is CHK1 and CHK2 inhibitor, which may enhance radiosensitivity of tumor cells (PMID: 20024691).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||colon carcinoma||not applicable||Radiotherapy + XL-844||Preclinical - Cell culture||Actionable||In a preclinical study, radiation effects were enhanced by the addition of XL-844 in colon carcinoma cells in culture, demonstrating inhibition of DNA repair, mitotic catastrophe, and decreased cell survival (PMID: 20024691).||20024691|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|