Therapy Detail

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Therapy Name H3B-8800
Synonyms
Therapy Description

H3B-8800 binds to the SF3B complex and modulates splicing events, preferentially kills splicesome mutant tumor cells (Blood 2016 128: 966)

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Drug Name Trade Name Synonyms Drug Classes Drug Description
H3B-8800 H3B-8800 binds to the SF3B complex and modulates splicing events, preferentially kills splicesome mutant tumor cells (PMID: 29457796, PMID: 31902291).

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  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
SF3B1 K700E acute myeloid leukemia sensitive H3B-8800 Preclinical - Pdx Actionable In a preclinical study, H3B-8800 inhibited aberrant splicing and tumor growth in a cell line xenograft and a patient-derived xenograft (PDX) model of acute myeloid leukemia harboring SF3B1 K700E (PMID: 29457796). 29457796
SF3B1 K700E acute myeloid leukemia sensitive H3B-8800 Preclinical - Cell culture Actionable In a preclinical study, H3B-8800 preferentially inhibited growth of mouse acute myeloid leukemia cells harboring SF3B1 K700E compared to SF3B1 wild-type cells in culture (Blood 2016 128:966). detail...
Unknown unknown chronic myelomonocytic leukemia not applicable H3B-8800 Preclinical - Pdx Actionable In a preclinical study, H3B-8800 treatment reduced tumor burden in patient-derived xenograft (PDX) models of chronic myelomonocytic leukemia harboring spliceosome mutations but not spliceosome wild-type models (Blood 2016 128:966). detail...
SRSF2 mutant chronic myelomonocytic leukemia sensitive H3B-8800 Preclinical - Pdx Actionable In a preclinical study, H3B-8800 inhibited tumor growth in patient-derived xenograft (PDX) models of chronic myelomonocytic leukemia harboring SRSF2 mutations, but not in SRSF2 wild-type PDX models (PMID: 29457796). 29457796
U2AF1 S34F lung cancer sensitive H3B-8800 Preclinical - Cell line xenograft Actionable In a preclinical study, H3B-8800 preferentially inhibited growth of lung cancer cells harboring U2AF1 S34F compared to U2AF1 wild-type cells in culture and in cell line xenograft models (Cancer Res 2017;77(13 Suppl):Abstract nr 1185). detail...
SRSF2 P95H acute myeloid leukemia sensitive H3B-8800 Preclinical - Cell line xenograft Actionable In a preclinical study, H3B-8800 inhibited tumor growth in a cell line xenograft model of acute myeloid leukemia harboring SRSF2 P95H (PMID: 29457796). 29457796
SF3B1 K700E chronic myeloid leukemia sensitive H3B-8800 Preclinical - Cell line xenograft Actionable In a preclinical study, H3B-8800 preferentially induced cell death in a chronic myeloid leukemia cell line expressing SF3B1 K700E in culture, inhibited aberrant splicing and tumor growth in a cell line xenograft model (PMID: 29457796). 29457796
SF3B1 K700E chronic myeloid leukemia sensitive H3B-8800 Preclinical - Cell line xenograft Actionable In a preclinical study, H3B-8800 inhibited tumor growth in cell line xenograft models of chronic myeloid leukemia harboring SF3B1 K700E while had no effect in SF3B1 wild-type controls (Blood 2016 128:966). detail...
SF3B1 K700E pancreatic cancer sensitive H3B-8800 Preclinical - Cell culture Actionable In a preclinical study, H3B-8800 inhibited aberrant splicing and preferentially induced apoptosis in pancreatic cancer cells harboring SF3B1 K700E compared to SF3B1 wild-type cell lines in culture (PMID: 29457796). 29457796
SF3B1 R1074H Advanced Solid Tumor resistant H3B-8800 Preclinical - Cell culture Actionable In a preclinical study, transformed cells overexpressing SF3B1 R1074H were resistant to H3B-8800 in culture (Blood 2016 128:966). detail...
SF3B1 R1074H colorectal cancer resistant H3B-8800 Preclinical - Cell culture Actionable In a preclinical study, a colorectal cancer cell line expressing SF3B1 R1074H was resistant to H3B-8800 in culture (PMID: 29457796). 29457796
KMT2A - MLLT3 SRSF2 P95H acute myeloid leukemia sensitive H3B-8800 Preclinical Actionable In a preclinical study, H3B-8800 inhibited tumor growth in transplant animal models of mouse acute myeloid leukemia cells harboring SRSF2 P95H and KMT2A-MLLT3 (MLL-AF9) while had no effect in SRSF2 wild-type controls (Blood 2016 128:966). detail...

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  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Clinical Trial Phase Therapies Title Recruitment Status
NCT02841540 Phase I H3B-8800 A Phase 1 Study to Evaluate H3B-8800 in Participants With Myelodysplastic Syndromes, Acute Myeloid Leukemia, and Chronic Myelomonocytic Leukemia Active, not recruiting


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