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LN145 comprises autologous tumor infiltrating lymphocytes that are isolated and expanded with IL-2, followed by infusion, potentially resulting in tumor cell death (NCI Drug Dictionary).
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|LN-145||LN145||LN145 comprises autologous tumor infiltrating lymphocytes that are isolated and expanded with IL-2, followed by infusion, potentially resulting in tumor cell death (NCI Drug Dictionary).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04111510||Phase II||LN-145||Autologous Tumor Infiltrating Lymphocytes in Patients With Pretreated Metastatic Triple Negative Breast Cancer||Active, not recruiting||USA||0|
|NCT03108495||Phase II||LN-145||Study of LN-145, Autologous Tumor Infiltrating Lymphocytes in the Treatment of Patients With Cervical Carcinoma||Recruiting||USA | ITA | FRA | ESP | DEU||3|
|NCT03083873||Phase II||LN-145||Study of LN-145 Autologous Tumor Infiltrating Lymphocytes in the Treatment of Squamous Cell Carcinoma of the Head & Neck||Completed||USA||0|
|NCT03419559||Phase II||LN-145 Durvalumab + LN-145||Study of Autologous Tumor Infiltrating Lymphocytes (LN-145) Alone and In Combo With Durvalumab in Non-Small Cell Lung Cancer||Withdrawn||USA||0|
|NCT03645928||Phase II||LN-144 + Pembrolizumab LN-145 LN-145 + Pembrolizumab||Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors||Recruiting||USA | FRA | ESP | DEU | CAN||3|
|NCT04614103||Phase II||LN-145||Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer||Recruiting||USA | DEU | CAN||1|