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Therapy Name MRG-106
Synonyms
Therapy Description

MRG-106 (cobomarsen) is an LNA-modified oligonucleotide that inhibits the microRNA miR-155-5p, which results in increased expression of miR-155-5p silenced genes and potentially leads to decreased proliferation and increased apoptosis of tumor cells (Blood 126.23 (2015): 3802, PMID: 30125933).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
MRG-106 Cobomarsen MRG-106 (cobomarsen) is an LNA-modified oligonucleotide that inhibits the microRNA miR-155-5p, which results in increased expression of miR-155-5p silenced genes and potentially leads to decreased proliferation and increased apoptosis of tumor cells (Blood 126.23 (2015): 3802, PMID: 30125933).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02580552 Phase I MRG-106 Safety, Tolerability and Pharmacokinetics of MRG-106 in Patients With Mycosis Fungoides (MF), CLL, DLBCL or ATLL Completed USA 0
NCT03837457 Phase II MRG-106 PRISM: Efficacy and Safety of Cobomarsen (MRG-106) in Subjects With Mycosis Fungoides Who Have Completed the SOLAR Study (PRISM) Terminated USA | FRA | BEL 0
NCT03713320 Phase II Vorinostat MRG-106 SOLAR: Efficacy and Safety of Cobomarsen (MRG-106) vs. Active Comparator in Subjects With Mycosis Fungoides (SOLAR) Terminated USA | ITA | GBR | FRA | ESP | CAN | BEL | AUS 0


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