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Therapy Name IMGN632
Synonyms
Therapy Description

IMGN632 is an antibody-drug conjugate comprised of an anti-CD123 antibody linked to a DNA alkylating agent, an indolinobenzodiazepine pseudodimer, which may result in cytotoxicty of cells expressing CD123 (PMID: 29661755, PMID: 30361418).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
IMGN632 IMGN 632|IMGN-632 IMGN632 is an antibody-drug conjugate comprised of an anti-CD123 antibody linked to a DNA alkylating agent, an indolinobenzodiazepine pseudodimer, which may result in cytotoxicty of cells expressing CD123 (PMID: 29661755, PMID: 30361418).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03386513 Phase Ib/II IMGN632 Study of IMGN632 in Patients With Untreated BPDCN and Relapsed/Refractory BPDCN Active, not recruiting USA | ITA | GBR | FRA | ESP | DEU 0
NCT04086264 Phase Ib/II IMGN632 IMGN632 + Venetoclax Azacitidine + IMGN632 Azacitidine + IMGN632 + Venetoclax IMGN632 as Monotherapy or With Venetoclax and/or Azacitidine for Participants With CD123-Positive Acute Myeloid Leukemia Active, not recruiting USA | ITA | GBR | FRA | ESP | DEU 0


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