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Therapy Name | CX-188 |
Synonyms | |
Therapy Description |
CX-188 is a PD-1 (PDCD1) probody, consisting of a monoclonal antibody conjugated to a linker that is cleaved by tumor proteases to unmask the antibody and inhibit signaling by PD-1 (NCI Drug Dictionary). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
CX-188 | CX188|CX 188 | Immune Checkpoint Inhibitor 147 PD-L1/PD-1 antibody 117 | CX-188 is a PD-1 (PDCD1) probody, consisting of a monoclonal antibody conjugated to a linker that is cleaved by tumor proteases to unmask the antibody and inhibit signaling by PD-1 (NCI Drug Dictionary). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT03706274 | Phase I | CX-188 | PROCLAIM-CX-188: A Trial to Find Safe and Active Doses of an Investigational Drug CX-188 for Patients With Solid Tumors | Withdrawn | USA | 0 |