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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|CH7057288||Trk Receptor Inhibitor (Pan) 23||CH7057288 selectivity inhibits NTRK1, 2, and 3, resulting in decreased downstream signaling and potentially resulting in reduced growth of tumors harboring NTRK fusions (PMID: 30242093).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ETV6 - NTRK3||acute myeloid leukemia||sensitive||CH7057288||Preclinical - Cell line xenograft||Actionable||In a preclinical study, CH7057288 inhibited NTRK phosphorylation and downstream signaling and reduced growth of acute myeloid leukemia cells harboring ETV6-NTRK3 in culture, and induced tumor regression in xenograft models (PMID: 30242093).||30242093|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|