Therapy Detail

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Therapy Name ARV-110
Synonyms
Therapy Description

ARV-110 is bifunctional molecule that targets androgen receptor (AR) for proteolytic degradation resulting in reduced target gene expression, potentially leading to decreased tumor growth inhibition and apoptosis (Journal of Clinical Oncology 37, no. 7_suppl (March 1 2019) 259-259).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ARV-110 Hormone - Anti-androgens 27 ARV-110 is bifunctional molecule that targets androgen receptor (AR) for proteolytic degradation resulting in reduced target gene expression, potentially leading to decreased tumor growth inhibition and apoptosis (Journal of Clinical Oncology 37, no. 7_suppl (March 1 2019) 259-259).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown prostate cancer not applicable ARV-110 Phase I Actionable In a Phase I trial, ARV-110 demonstrated safety and preliminary efficacy, resulted in an over 50% decline of PSA in 13.3% (2/15) of patients with metastatic castrate-resistant prostate cancer (J Clin Oncol 38: 2020 (suppl; abstr 3500); NCT03888612). detail...

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status
NCT03888612 Phase I ARV-110 A Phase 1 Clinical Trial of ARV-110 in Patients With Metastatic Castration-resistant Prostate Cancer. (mCRPC) Recruiting


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