Therapy Detail

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Therapy Name Lacutamab
Synonyms
Therapy Description

IPH4102 is a monoclonal antibody that targets KIR3DL2, which potentially results in increased anti-tumor immune response against KIR3DL2-expressing tumor cells, and reduced tumor growth (PMID: 25361998, PMID: 31253572).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Lacutamab IPH-4102|IPH 4102|IPH4102 Lacutamab (IPH4102) is a monoclonal antibody that targets KIR3DL2, which potentially results in increased anti-tumor immune response against KIR3DL2-expressing tumor cells, and reduced tumor growth (PMID: 25361998, PMID: 31253572).

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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Sezary's disease not applicable Lacutamab Phase I Actionable In a Phase I trial, Lacutamab (IPH4102) demonstrated safety, and treatment resulted in an overall response rate of 43% (15/35; 2 complete responses, 13 partial responses), a median progression-free survival (PFS) of 11.7 months, and a median duration of response (DOR) of 13.8 months in patients with Sezary syndrome, with a median PFS of 16.8 months, and a median DOR of 13.8 months in Sezary syndrome patients with prior Poteligeo (mogamulizumab-kpkc) treatment (PMID: 31253572; NCT02593045). 31253572
Unknown unknown mycosis fungoides not applicable Lacutamab Phase I Actionable In a Phase I trial, Lacutamab (IPH4102) demonstrated safety, and treatment resulted in a median progression-free survival of 3.9 months, and a response in 1 and stable disease in 7 of 8 patients with mycosis fungoides (PMID: 31253572; NCT02593045). 31253572
Unknown unknown cutaneous T cell lymphoma not applicable Lacutamab Phase I Actionable In a Phase I trial, Lacutamab (IPH4102) demonstrated safety, and cutaneous T-cell lymphoma patients treated with IPH4102 demonstrated an overall response rate of 36% (16/44), a median progression-free survival of 8.2 months, and a median duration of response of 13.8 months (PMID: 31253572; NCT02593045). 31253572

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Clinical Trial Phase Therapies Title Recruitment Status
NCT03902184 Phase II Gemcitabine + Lacutamab + Oxaliplatin Lacutamab IPH4102 Alone or in Combination With Chemotherapy in Patients With Advanced T Cell Lymphoma (TELLOMAK) Recruiting


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