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|Therapy Name||Dexamethasone + Thalidomide|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Thalidomide||Thalomid||N-Phthalimidoglutamic acid imide||Thalomid (thalidomide) is a a racaemic glutamic acid analogue that has anti-inflammatory, anti-angiogenic, immunosuppressive, and anti-tumor activities (PMID: 15172781). Thalomid (thalidomide) is approved for use in combination with dexamethasone for patients with newly diagnosed multiple myeloma (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||multiple myeloma||not applicable||Dexamethasone + Thalidomide||FDA approved||Actionable||In a Phase III trial that supported FDA approval, Thalomid (thalidomide) in combination with dexamethasone (n=103) resulted in significantly improved response rate (63% vs 41%, p=0.0017) compared to dexamethasone alone (n=104) in patients with newly diagnosed multiple myeloma (PMID: 16365178).||16365178 detail...|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|