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Therapy Name CX-2029
Synonyms
Therapy Description

CX-2029 is a probody-drug conjugate that consists of CD71-targeted monoclonal antibody linked to a antigen-binding site masking peptide that is conjugated to the anti-microtubule agent monomethyl auristatin E (MMAE), which potentially induces cell cycle arrest and apoptosis of CD71-expressing tumor cells (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CX-2029 PDC-targeting CD71 CX-2029|CX 2029 CX-2029 is a probody-drug conjugate that consists of CD71-targeted monoclonal antibody linked to a antigen-binding site masking peptide that is conjugated to the anti-microtubule agent monomethyl auristatin E (MMAE), which potentially induces cell cycle arrest and apoptosis of CD71-expressing tumor cells (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03543813 Phase Ib/II CX-2029 PROCLAIM-CX-2029: A Trial to Find Safe and Active Doses of an Investigational Drug CX-2029 for Patients With Solid Tumors or DLBCL Completed USA | GBR | ESP 1


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