Therapy Detail

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Therapy Name CX-2029
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CX-2029 PDC-targeting CD71 CX-2029|CX 2029 CX-2029 is a probody-drug conjugate that consists of CD71-targeted monoclonal antibody linked to a antigen-binding site masking peptide that is conjugated to the anti-microtubule agent monomethyl auristatin E (MMAE), which potentially induces cell cycle arrest and apoptosis of CD71-expressing tumor cells (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown lung squamous cell carcinoma not applicable CX-2029 Case Reports/Case Series Actionable In a Phase I/II trial (PROCLAIM-CX-2029), CX-2029 treatment resulted in partial response in a patient with squamous cell carcinoma of the lung (J Clin Oncol 38: 2020 (suppl; abstr 3502); NCT03543813). detail...
Unknown unknown Advanced Solid Tumor not applicable CX-2029 Phase Ib/II Actionable In a Phase I/II trial (PROCLAIM-CX-2029), CX-2029 treatment demonstrated acceptable safety, and resulted in a partial response in 3.1% (1/32) and stable disease in 28.1% (9/32) of patients with advanced solid tumors (J Clin Oncol 38: 2020 (suppl; abstr 3502); NCT03543813). detail...
Unknown unknown ocular melanoma not applicable CX-2029 Case Reports/Case Series Actionable In a Phase I/II trial (PROCLAIM-CX-2029), CX-2029 treatment resulted in stable in a patient with ocular melanoma who stayed on treatment for 36 weeks (J Clin Oncol 38: 2020 (suppl; abstr 3502); NCT03543813). detail...

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status
NCT03543813 Phase Ib/II CX-2029 PROCLAIM-CX-2029: A Trial to Find Safe and Active Doses of an Investigational Drug CX-2029 for Patients With Solid Tumors or DLBCL Recruiting


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