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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|MAK683||MAK 683|EED PPI inhibitor MAK683||MAK683 blocks the interaction between EED and EZH2, potentially resulting in a loss of PRC2 activity, reduced H3K27 trimethylation, and decreased proliferation of tumor cells (J Clin Oncol 40, no. 16_suppl (June 01, 2022) 3083, PMID: 36858198).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT02900651||Phase Ib/II||MAK683||Safety and Efficacy of MAK683 in Adult Patients With Advanced Malignancies||Active, not recruiting||USA | ITA | FRA | ESP | DEU | CAN||4|