Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|MAK683||MAK 683|EED PPI inhibitor MAK683||MAK683 is an inhibitor of EED, which blocks the interaction between EED and EZH2, potentially resulting in a loss of PRC2 activity and reduced H3K27 trimethylation and decreased proliferation of tumor cells (NCI Drug Dictionary).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT02900651||Phase Ib/II||MAK683||Safety and Efficacy of MAK683 in Adult Patients With Advanced Malignancies||Recruiting|