Therapy Detail

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Therapy Name BTX-A51
Synonyms
Therapy Description

BTX-A51 is a small molecule inhibitor of CSNK1A1, CDK7, and CDK9, which may lead to Tp53 stabilization and apoptotic induction, inhibition of colony formation, and antitumor activity (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
BTX-A51 BTXA51 CDK7 Inhibitor 16 CDK9 Inhibitor 21 BTX-A51 is a small molecule inhibitor of CSNK1A1, CDK7, and CDK9, which may lead to Tp53 stabilization and apoptotic induction, inhibition of colony formation, and antitumor activity (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04872166 Phase I BTX-A51 A Study of BTX-A51 in People With Advanced Solid Tumor and Breast Cancer Recruiting USA 0
NCT06414434 Phase I BTX-A51 BTX-A51 in Patients With Liposarcoma Not yet recruiting USA 0
NCT04243785 Phase I BTX-A51 A Study of BTX-A51 in People With Relapsed or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome Recruiting USA 0


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