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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|SLC-391||SLC391|SLC 391||AXL Inhibitor 27||SLC-391 is an Axl inhibitor that blocks the phosphotransferase activity of Axl, which potentially stimulates anti-tumor immune response and reverses immunosuppression leading to tumor growth inhibition (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr B148).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||colon carcinoma||not applicable||SLC-391||Preclinical||Actionable||In a preclinical study, SLC-391 treatment did not inhibit proliferation of a colon carcinoma cell line in culture, however, inhibited tumor growth by 37% in a syngeneic mouse model (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr B148).||detail...|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT03990454||Phase I||SLC-391||Safety Study of SLC-391 in Subjects With Solid Tumors||Recruiting|