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Therapy Name BAY2402234
Synonyms
Therapy Description

BAY2402234 is a small molecule inhibitor that selectively binds to and inhibits dihydroorotate dehydrogenase (DHODH), which induces differentiation of blast cells and potentially leads to cell cycle arrest, decreased proliferation, increased apoptosis, and tumor growth inhibition (PMID: 30940908).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
BAY2402234 BAY-2402234|BAY 2402234 BAY2402234 is a small molecule inhibitor that selectively binds to and inhibits dihydroorotate dehydrogenase (DHODH), which induces differentiation of blast cells and potentially leads to cell cycle arrest, decreased proliferation, increased apoptosis, and tumor growth inhibition (PMID: 30940908).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03404726 Phase I BAY2402234 A Study to Investigate BAY2402234, a Dihydroorotate Dehydrogenase (DHODH) Inhibitor, in Myeloid Malignancies Terminated USA | FRA 0


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