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Therapy Name ORCA-010
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ORCA-010 ORCA 010|ORCA010 ORCA-010 is an engineered oncolytic serotype 5 adenovirus (Ad5), which potentially induces enhanced cytotoxicity against tumor cells and inhibits tumor growth (PMID: 25093639).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown lung adenocarcinoma not applicable ORCA-010 Preclinical - Cell line xenograft Actionable In a preclinical study, ORCA-010 treatment induced cytotoxicity in a lung adenocarcinoma cell line in culture, and inhibited tumor growth and increased survival in a cell line xenograft model (PMID: 25093639). 25093639
Unknown unknown ovarian cancer not applicable ORCA-010 Preclinical - Cell line xenograft Actionable In a preclinical study, ORCA-010 treatment inhibited tumor growth and increased survival in a cell line xenograft model of ovarian cancer (PMID: 25093639). 25093639
Unknown unknown prostate cancer not applicable ORCA-010 Preclinical - Cell line xenograft Actionable In a preclinical study, ORCA-010 treatment induced cytotoxicity in a prostate cancer cell line in culture, and inhibited tumor growth and increased survival in a cell line xenograft model (PMID: 25093639). 25093639

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status
NCT04097002 Phase Ib/II ORCA-010 First in Man Clinical Study to Evaluate Safety and Tolerability of an Oncolytic Adenovirus in Prostate Cancer Patients. Recruiting


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