Disease Detail


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ID DOID:3275
Name thymoma
Definition A thymus cancer that derives_from epithelial cells located_in the thymus. The tumor cells in a thymoma look similar to the normal cells of the thymus, grow slowly, and rarely spread beyond the thymus.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer immune system cancer thymus cancer thymoma


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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
TP53 loss Selinexor thymoma predicted - resistant detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01011439 Phase II Milciclib Phase II Study Of Oral PHA-848125AC In Patients With Thymic Carcinoma Terminated USA | ITA | FRA 0
NCT01025089 Phase II Cetuximab Cisplatin + Cyclophosphamide + Doxorubicin Chemotherapy Plus Cetuximab Followed by Surgical Resection in Patients With Locally Advanced or Recurrent Thymoma or Thymic Carcinoma Active, not recruiting USA 0
NCT01301391 Phase II Milciclib Study Of Oral PHA-848125AC In Patients With Malignant Thymoma Previously Treated With Multiple Lines Of Chemotherapy Terminated USA | ITA 0
NCT01621568 Phase II Sunitinib Sunitinib for Advanced Thymus Cancer Following Earlier Treatment Active, not recruiting USA 0
NCT02220855 Phase II Buparlisib A Study of BKM120 (Buparlisib) in Relapsed or Refractory Thymomas Completed USA 0
NCT02721732 Phase II Pembrolizumab Study for the Evaluation of Efficacy of Pembrolizumab (MK-3475) in Patients With Rare Tumors Active, not recruiting USA 0
NCT03023319 Phase I Bosutinib + Pemetrexed Disodium Bosutinib in Combination With Pemetrexed in Patients With Selected Metastatic Solid Tumors Completed USA 0
NCT03076554 Phase II Avelumab A Pilot Study to Investigate the Safety and Clinical Activity of Avelumab (MSB0010718C) in Thymoma and Thymic Carcinoma After Progression on Platinum-Based Chemotherapy Recruiting USA 0
NCT03134118 Phase II Nivolumab Nivolumab in Patients With Type B3 Thymoma and Thymic Carcinoma (NIVOTHYM) (NIVOTHYM) Active, not recruiting NLD | GBR | FRA | ESP | BEL 1
NCT03193437 Phase II Selinexor Selinexor in Patients With Advanced Thymic Epithelial Tumor Progressing After Primary Chemotherapy Terminated USA 0
NCT03295227 Phase I Pembrolizumab Feasibility Trial of Pembrolizumab in Unresectable Thymoma and Thymic Carcinoma Recruiting USA 0
NCT03449173 Phase II Sunitinib Trial of Sunitinib in Patients With Type B3 Thymoma or Thymic Carcinoma in Second and Further Lines (Style Trial) (Style) Unknown status ITA 0
NCT03517488 Phase I XmAb20717 A Study of XmAb20717 in Subjects With Selected Advanced Solid Tumors (DUET-2) Completed USA 0
NCT03556228 Phase I VMD-928 Selective TrkA Inhibitor VMD-928 to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma Recruiting USA 1
NCT04417660 Phase II Bintrafusp alfa Bintrafusp Alfa (M7824) in Subjects With Thymoma and Thymic Carcinoma Recruiting USA 0
NCT04710628 Phase II Lenvatinib + Pembrolizumab Combination of Pembrolizumab and Lenvatinib, in Pre-treated Thymic CArcinoma paTIents (PECATI) Active, not recruiting ITA | FRA | ESP 0
NCT05228015 Phase I IK-930 Oral TEAD Inhibitor Targeting the Hippo Pathway in Subjects With Advanced Solid Tumors Recruiting USA | GBR 0
NCT06248515 Phase II Sacituzumab govitecan-hziy A Phase II Trial of Sacituzumab Govitecan in Patients With Advanced Thymic Epithelial Tumors Recruiting USA 0