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ID | DOID:349 |
Name | systemic mastocytosis |
Definition | |
Source | DiseaseOntology.org |
Alt Ids | |
Path | disease disease of anatomical entity hematopoietic system disease leukocyte disease mastocytosis systemic mastocytosis |
Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
---|---|---|---|---|
KIT D816V | Imatinib | systemic mastocytosis | resistant | detail... |
KIT D816V | Avapritinib | systemic mastocytosis | sensitive | detail... |
KIT D816V | N/A | systemic mastocytosis | not applicable | detail... |
KIT D816X | N/A | systemic mastocytosis | not applicable | detail... |
CBL mutant | N/A | systemic mastocytosis | not applicable | detail... |
KIT K509I | Imatinib | systemic mastocytosis | sensitive | detail... |
KIT K509I | Dasatinib | systemic mastocytosis | sensitive | detail... |
KIT K509I | Midostaurin | systemic mastocytosis | predicted - sensitive | detail... |
KIT F522C | Imatinib | systemic mastocytosis | sensitive | detail... |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT04681105 | Phase I | Acetaminophen + Dexamethasone + Diphenhydramine + Flotetuzumab + Ranitidine Dexamethasone + Diphenhydramine + Flotetuzumab + Ibuprofen + Ranitidine | Flotetuzumab for the Treatment of Relapsed or Refractory Advanced CD123-Positive Hematological Malignancies | Recruiting | USA | 0 |
NCT04996875 | Phase II | PLX9486 | (Apex) CGT9486 in Patients With Advanced Systemic Mastocytosis | Recruiting | USA | FRA | ESP | CAN | 1 |