Disease Detail

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
Unknown unknown Dasatinib + Vandetanib brain glioma not applicable detail...
Unknown unknown Cabozantinib brain glioma not applicable detail...
Unknown unknown Adavosertib brain glioma not applicable detail...
Unknown unknown Nintedanib brain glioma not applicable detail...
Unknown unknown Dorsomorphin brain glioma not applicable detail...
PTEN loss Gedatolisib brain glioma sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT00602667 Phase I Cisplatin + Cyclophosphamide + Methotrexate + Vincristine Cyclophosphamide + Etoposide + Topotecan Cyclophosphamide + Erlotinib + Topotecan Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma Active, not recruiting
NCT00660621 Phase II Bevacizumab + Temozolomide A Phase II Study Of Gliadel, Concomitant Temozolomide And Radiation, Followed By Dose Dense Therapy With Temozolomide Plus Bevacizumab For Newly Diagnosed Malignant High Grade Glioma Unknown status
NCT00823459 Phase II Everolimus Phase II Trial of RAD001 in Patients With Recurrent Low Grade Glioma Completed
NCT01390948 Phase II Temozolomide Bevacizumab A Study of Avastin (Bevacizumab) in Combination With Temolozomide (TMZ) and Radiotherapy in Paediatric and Adolescent Patients With High-Grade Glioma Active, not recruiting
NCT01580969 Phase Ib/II Bevacizumab Repeat Radiation, Minocycline and Bevacizumab in Patients With Recurrent Glioma Completed
NCT01661400 Phase I Cyclophosphamide Thalidomide Anti-Angiogenic Therapy Post Transplant (ASCR) for Relapsed and Refractory Pediatric Solid Tumors Recruiting
NCT01672463 Phase I OKN-007 Clinical Trial of IV OKN-007 in a Pilot Cohort of Human Recurrent Malignant Glioma Patients Recruiting
NCT01774253 Phase II Vismodegib Erivedge (Vismodegib) in the Treatment of Pediatric Patients With Refractory Pontine Glioma Terminated
NCT01967810 Phase II Bevacizumab GRN1005 ANG1005 in Patients With Recurrent High-Grade Glioma Completed
NCT02124772 Phase I Trametinib Dabrafenib + Trametinib Study to Investigate Safety, Pharmacokinetic (PK), Pharmacodynamic (PD) and Clinical Activity of Trametinib in Subjects With Cancer or Plexiform Neurofibromas and Trametinib in Combination With Dabrafenib in Subjects With Cancers Harboring V600 Mutations Recruiting
NCT02372006 Phase Ib/II Afatinib Trial of Afatinib in Pediatric Tumours Recruiting
NCT03122197 Phase I Letrozole Study of Letrozole in Recurrent Gliomas Recruiting
NCT03363217 Phase Ib/II Trametinib Trametinib for Pediatric Neuro-oncology Patients With Refractory Tumor and Activation of the MAPK/ERK Pathway. Recruiting
NCT03429803 Phase Ib/II MLN2480 TAK-580 In Gliomas and Other Tumors Recruiting
NCT03576612 Phase I AdV-tk Temozolomide Valacyclovir Nivolumab GMCI, Nivolumab, and Radiation Therapy in Treating Patients With Newly Diagnosed High-Grade Gliomas (GMCI) Recruiting
NCT03796273 Phase I Ketoconazole Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases Recruiting