Disease Detail


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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
PTEN loss Gedatolisib brain glioma sensitive detail...
IDH1 act mut LY3410738 brain glioma predicted - sensitive detail...
IDH2 act mut LY3410738 brain glioma predicted - sensitive detail...
IDH1 R132X Olutasidenib brain glioma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT00660621 Phase II Bevacizumab + Temozolomide A Phase II Study Of Gliadel, Concomitant Temozolomide And Radiation, Followed By Dose Dense Therapy With Temozolomide Plus Bevacizumab For Newly Diagnosed Malignant High Grade Glioma Unknown status USA 0
NCT00823459 Phase II Everolimus Phase II Trial of RAD001 in Patients With Recurrent Low Grade Glioma Completed USA 0
NCT01390948 Phase II Temozolomide Bevacizumab A Study of Avastin (Bevacizumab) in Combination With Temolozomide (TMZ) and Radiotherapy in Paediatric and Adolescent Patients With High-Grade Glioma Completed NLD | ITA | GBR | FRA | ESP | CAN | BEL | AUT | AUS 5
NCT01580969 Phase Ib/II Bevacizumab Repeat Radiation, Minocycline and Bevacizumab in Patients With Recurrent Glioma Completed USA 0
NCT01661400 Phase I Cyclophosphamide Thalidomide Anti-Angiogenic Therapy Post Transplant (ASCR) for Relapsed and Refractory Pediatric Solid Tumors Completed USA 0
NCT01672463 Phase I OKN-007 Clinical Trial of IV OKN-007 in a Pilot Cohort of Human Recurrent Malignant Glioma Patients Active, not recruiting USA 0
NCT01774253 Phase II Vismodegib Erivedge (Vismodegib) in the Treatment of Pediatric Patients With Refractory Pontine Glioma Terminated USA 0
NCT01967810 Phase II Bevacizumab Paclitaxel Trevatide ANG1005 in Patients With Recurrent High-Grade Glioma Completed USA 0
NCT02124772 Phase I Trametinib Dabrafenib + Trametinib Study to Investigate Safety, Pharmacokinetic (PK), Pharmacodynamic (PD) and Clinical Activity of Trametinib in Subjects With Cancer or Plexiform Neurofibromas and Trametinib in Combination With Dabrafenib in Subjects With Cancers Harboring V600 Mutations Completed USA | GBR | FRA | CAN | AUS 0
NCT02372006 Phase Ib/II Afatinib Trial of Afatinib in Pediatric Tumours Completed USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | AUT | AUS 2
NCT03122197 Phase I Letrozole Study of Letrozole in Recurrent Gliomas Recruiting USA 0
NCT03363217 Phase Ib/II Trametinib Trametinib for Pediatric Neuro-oncology Patients With Refractory Tumor and Activation of the MAPK/ERK Pathway. Active, not recruiting CAN 0
NCT03429803 Phase I Tovorafenib DAY101 In Gliomas and Other Tumors Active, not recruiting USA 0
NCT03576612 Phase I AdV-tk Temozolomide Valacyclovir Nivolumab GMCI, Nivolumab, and Radiation Therapy in Treating Patients With Newly Diagnosed High-Grade Gliomas (GMCI) Active, not recruiting USA 0
NCT03796273 Phase I Ketoconazole Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases Recruiting USA 0
NCT03871257 Phase III Carboplatin + Vincristine Sulfate Selumetinib A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma Recruiting USA | CAN 1
NCT04544007 Phase II Poly ICLC A Phase II Trial of Poly-ICLC for Low-Grade Gliomas (NF111) Recruiting USA 0
NCT04908176 Phase I Avapritinib + Midazolam A Drug-drug Interaction Study of Avapritinib and Midazolam Active, not recruiting USA 0