Disease Detail


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ID DOID:80187
Name chronic neutrophilic leukemia
Definition A chronic leukemia characterized by neutrophilic leukocytosis with no detectable Philadelphia chromosome or BCR/ABL fusion gene.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer hematologic cancer leukemia chronic leukemia chronic neutrophilic leukemia


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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
CSF3R S783fs Dasatinib chronic neutrophilic leukemia predicted - sensitive detail...
CSF3R S783fs Pyridone 6 chronic neutrophilic leukemia predicted - resistant detail...
CSF3R S783fs Tofacitinib chronic neutrophilic leukemia predicted - resistant detail...
CSF3R S783fs Momelotinib chronic neutrophilic leukemia predicted - resistant detail...
CSF3R N579Y CSF3R Q739* CSF3R Q741* Ruxolitinib chronic neutrophilic leukemia predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02092324 Phase II Ruxolitinib Ruxolitinib Phosphate in Treating Patients With Chronic Neutrophilic Leukemia or Atypical Chronic Myeloid Leukemia Completed USA 0
NCT03862157 Phase Ib/II Azacitidine + MLN4924 + Venetoclax Azacitidine, Venetoclax, and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Active, not recruiting USA 0
NCT05177211 Phase II Fedratinib Fedratinib in Myelodysplastic /Myeloproliferative Neoplasms (MDS/MPNs) and Chronic Neutrophilic Leukemia (CNL) Recruiting USA 0