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ID DOID:9254
Name mast-cell leukemia
Definition A leukemia that results_in an overwhelming number of tissue mast cells located_in peripheral blood.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer hematologic cancer leukemia mast-cell leukemia

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
KIT V560G KIT D816V Dasatinib mast-cell leukemia sensitive detail...
KIT V560G KIT D816V Ponatinib mast-cell leukemia sensitive detail...
KIT V560G KIT D816V BPR1J373 mast-cell leukemia sensitive detail...
KIT S476I Midostaurin mast-cell leukemia predicted - sensitive detail...
KIT S476I Nilotinib mast-cell leukemia predicted - sensitive detail...
KIT V560G KIT D816V Avapritinib mast-cell leukemia sensitive detail...
KIT V560G Avapritinib mast-cell leukemia sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02415608 Phase II Ibrutinib Ibrutinib in Treating Patients With Advanced Systemic Mastocytosis Terminated USA 0
NCT03214666 Phase Ib/II GTB-3550 TriKE GTB-3550 Tri-Specific Killer Engager (TriKE®) for High Risk Hematological Malignancies Terminated USA 0
NCT03580655 Phase II Avapritinib (PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis Active, not recruiting USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | AUT 3
NCT04996875 Phase II PLX9486 (Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis Recruiting USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUT | AUS 2
NCT05609942 Phase Ib/II Elenestinib Azacitidine + Elenestinib Study of Elenestinib (BLU-263) in Advanced Systemic Mastocytosis (AdvSM) and and Other KIT Altered Hematologic Malignancies (AZURE) Recruiting USA | NLD | FRA | ESP | DEU | BEL 1