Drug Detail


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Drug Name SGN-TGT
Trade Name
Drug Descriptions

SGN-TGT is a nonfucosylated monoclonal antibody that targets TIGIT, thereby preventing its interaction with CD112 and CD155 and enhancing the interaction of CD112 and CD155 with CD226 expressed on immune cells, which may lead to activation of an anti-tumor immune response (NCI Drug Dictionary, Cancer Res (2023) 83 (8_Supplement): CT265).

DrugClasses TIGIT Antibody 19
CAS Registry Number NA
NCIT ID C173630


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Axitinib + PF-06801591 + SGN-TGT Axitinib PF-06801591 SGN-TGT 0 1
Pembrolizumab + SGN-TGT Pembrolizumab SGN-TGT 0 1

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