Drug Detail


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Drug Name Glesatinib
Trade Name
Synonyms MGCD265
Drug Descriptions

Glesatinib (MGCD265) inhibits several tyrosine kinases including MET (type II inhibitor), MST1R (RON), and AXL, as well as VEGFR1-3, and TIE2, which may result in decreased tumor growth (PMID: 25806189, PMID: 26555154, PMID: 32306194).

DrugClasses AXL Inhibitor 29 MET Inhibitor 53 RON Inhibitor 11 VEGFR Inhibitor (Pan) 33
CAS Registry Number 936694-12-1
NCIT ID C77876


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Docetaxel + Glesatinib Docetaxel Glesatinib 0 1
Erlotinib + Glesatinib Erlotinib Glesatinib 0 1
Glesatinib Glesatinib 0 2
Glesatinib + Nivolumab Glesatinib Nivolumab 0 1

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