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Drug Name | Bardoxolone methyl |
Trade Name | |
Synonyms | CDDO-Me|RTA 402 |
Drug Descriptions |
Bardoxolone methyl (CDDO-Me) is a derivative of a synthetic triterpenoid, 2-cyano-3,12-dioxooleana- 1,9-dien-28-oic acid (CDDO), which targets KEAP1, leading to the activation of NRF2, and also binds to IKKB and inhibits NF-KB activation. CDDO-Me is developed for the treatment of inflammation and cancer (PMID: 25364233, PMID: 32370011) |
DrugClasses | |
CAS Registry Number | 218600-53-4 |
NCIT ID | C98250 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Bardoxolone methyl | Bardoxolone methyl | 0 | 0 |