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Go6976 binds and inhibits the calcium-dependent protein kinase C (PKC) isoforms, as well as Flt3, and mutant and wild-type Jak2, which may promote apoptosis and tumor regression (PMID: 8486620, PMID: 16956345).
|DrugClasses||FLT3 Inhibitor 50 JAK2 Inhibitor 17 PKC alpha Inhibitor 6 PKC beta Inhibitor 6|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|