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Drug Name O6-benzylguanine
Trade Name
Synonyms O6-BG|NSC-637037
Drug Descriptions

O6-benzylguanine is a guanine analogue that binds and inhibits O6-alkylguanine-DNA alkyltransferase (AGT), thereby inhibiting DNA repair (PMID: 9815757, PMID: 25407559).

CAS Registry Number 19916-73-5


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carmustine + Filgrastim + O6-benzylguanine + Temozolomide Carmustine Filgrastim O6-benzylguanine Temozolomide 0 1
O6-benzylguanine O6-benzylguanine 0 2
O6-benzylguanine + Temozolomide O6-benzylguanine Temozolomide 0 1

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