Drug Detail


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Drug Name Siltuximab
Trade Name Sylvant
Synonyms CNTO 328|CNTO328
Drug Descriptions

Sylvant (siltuxmab) is an anti-IL-6 chimeric monoclonal antibody, which inhibits IL6 signaling and may lead to decreased tumor cell growth (PMID: 26170629, PMID: 26744529). Sylvant (siltuximab) is FDA approved for patients with multicentric Castleman's disease who do not have HIV or HHV-8 (FDA.gov).

CAS Registry Number 541502-14-1
NCIT ID C61084


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Siltuximab Siltuximab 0 5
Siltuximab + Spartalizumab Siltuximab Spartalizumab 0 1

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