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Sylvant (siltuxmab) is an anti-IL-6 chimeric monoclonal antibody, which inhibits IL6 signaling and may lead to decreased tumor cell growth (PMID: 26170629, PMID: 26744529). Sylvant (siltuximab) is FDA approved for patients with multicentric Castleman's disease who do not have HIV or HHV-8 (FDA.gov).
|CAS Registry Number||541502-14-1|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Siltuximab + Spartalizumab||Siltuximab Spartalizumab||0||1|