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Drug Name TAS-114
Trade Name
Drug Descriptions

TAS-114 is a dual inhibitor of deoxyuridine triphosphatase (dUTPase) and dihydropyrimidine dehydrogenase (DPD), which may enhance anti-tumor activity of 5-FU through modulating its metabolism (PMID: 24452393, PMID: 30511200, PMID: 32700159, PMID: 32246224).

CAS Registry Number NA
NCIT ID C116885


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Capecitabine + TAS-114 Capecitabine TAS-114 0 1
TAS-114 TAS-114 0 0
TAS-114 + Tegafur-gimeracil-oteracil Potassium TAS-114 Tegafur-gimeracil-oteracil Potassium 0 1

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